Table 1.

Significance levels of the fallback and treatment-by-biomarker interaction approaches that satisfy Poverall = 0.015 and Psubset = 0.01 under the global null effects

Fallback approachTreatment-by-biomarker interaction approach
p+α1α2α3α4
0.10.01500.01100.01670.0100
0.30.01500.01200.01670.0110
0.50.01500.01400.01670.0130

NOTE: The significance level of the interaction test was specified as αINT = 0.1. We supposed E+ = p+E for calculating significance levels α3 and α4 in the treatment-by-biomarker interaction approach.