Probability | Traditional | Fixed-sequence-1 | Fixed-sequence-2 | MaST | Fallback | Treatment-by-biomarker interaction |
---|---|---|---|---|---|---|
Asymptotic approximations | ||||||
P_{overall} | 0.025 | 0.001 | 0.005 | 0.003 | 0.015 | 0.015 |
P_{subset} | 0.000 | 0.024 | 0.020 | 0.021 | 0.010 | 0.010 |
P_{success} | 0.025 | 0.025 | 0.025 | 0.024 | 0.025 | 0.025 |
Simulations^{a} | ||||||
P_{overall} | 0.026 | 0.001 | 0.005 | 0.003 | 0.015 | 0.015 |
P_{subset} | 0.000 | 0.023 | 0.018 | 0.020 | 0.010 | 0.010 |
P_{success} | 0.026 | 0.023 | 0.023 | 0.023 | 0.026 | 0.025 |
↵^{a}Exponential survival times were generated in the B^{+} and B^{−} patients with the baseline event rates, λ_{+} = λ_{−} = 1.0, and treatment effects (HR_{+}, HR_{−}) for a total number of patients of 200. Survival times were uncensored, so that E_{+} = p_{+}E holds. Use of other values of the baseline hazards λ_{+} and λ_{−} (possibly λ_{+} ≠ λ_{−}) may not change the results with the use of the stratified statistic Z_{overall} for the overall test given in the Appendix. Ten thousand simulations were conducted for each configuration.