Table 3.

Multivariable model for distant metastasis including clinical and biomarker covariates (N = 372)

Subdistribution HR (95% CI)P
Ki-67a1.53 (1.28–1.82)<0.0001
Cox-2a1.37 (1.01–1.84)0.040
p16a0.74 (0.60–0.92)0.0065
MDM2 (≥184 vs. <184)1.73 (1.04–2.84)0.036
Treatment (LTADT vs. STADT)2.53 (1.58–4.04)0.0001
Gleason score (≥8 vs. < 8)3.11 (1.99–4.85)<0.0001
Stage (T3/4 vs. T2)1.48 (0.93–2.36)0.098
Age (per year)0.96 (0.93–1.00)0.026
Initial PSA (per 10 units)1.003 (0.98–1.09)0.21
  • aContinuous scale, standardized.