Table 2.

All-grade adverse reactions in ≥20% of patients or grade 3/4 adverse reactions in ≥5% of patients in either study

MCL (N = 111)CLL (N = 48)
System organ classAll gradesGrades 3/4All gradesGrades 3/4
Preferred term%%%%
Gastrointestinal disorders
 Diarrhea515634
 Nausea310212
 Constipation250232
 Abdominal pain245150
 Vomiting230192
 Stomatitis171210
Infections and infestations
 Upper respiratory tract infection340482
 Pneumonia147108
 Sinusitis131216
 Skin infection145176
General disorders and administrative site conditions
 Fatigue415314
 Peripheral edema353230
 Pyrexia181252
Musculoskeletal and connective tissue disorders
 Musculoskeletal pain371276
 Arthralgia110230
Skin and subcutaneous tissue disorders
 Bruising300542
 Rash253270
Respiratory, thoracic, and mediastinal disorders
 Dyspnea274100
Metabolism and nutrition disorders
 Decreased appetite212172
Nervous system disorders
 Dizziness140210
Cardiac disorders
 Atrial fibrillation86198
Vascular disorders
 Hypertension104178
Hematology laboratory abnormalities
 Platelets decreased57177110
 Neutrophils decreased47295427
 Hemoglobin decreased419440