Table 1.

Clinical and pathologic features of five patients with colorectal cancer

HistopathologyMutational status
ModelGenderAge, yPrior chemotherapyLocationTypeTNMStageDegree of tumor differentiation (Grade)KRASBRAFPIK3CAAPCTP53p16 methylation statusMicrosatellite instability status
UM-CRM 12-1159M51UnknownLiverADCUnknownUnknownModerateWTWTH1047RWTp.Y102CUnknownUnknown
UM-CRM 13-180F72NoLeft ovaryADCpT3N1aM1aIVAModerateG12VWTWTWTp.R248WUnmethylatedMSS
UM-CRC 13-983F69NoRight/Left colonADCpT3N1cIIIBModerateWTV600EWTUnknownp.A6VMethylatedMSI
UM-CRC 13-1333F53NoSigmoid colonADCpT3N1bIIIBModerateG12DWTQ546Lp.R1432XWTUnmethylatedMSS
UM-CRC 14-136M54NoRight colonMUCpT3N0IIAModerateQ61HWTE542KUnknownUnknownUnmethylatedMSS

Abbreviations: ADC, adenocarcinoma; MSI, microsatellite instable; MSS, microsatellite stable; MUC, mucinous; WT, wild-type.