Table 1.

On-study AEs > 10% of total and grade 3 or 4 (all patients)

Total, n (%)Grade 3, n (%)Grade 4, n (%)
Total116 (100)81 (70)34 (29)
Nausea79 (68)11 (9)0
Diarrhea65 (56)8 (7)0
Vomiting42 (36)6 (5)0
Fatigue34 (29)5 (4)0
Abdominal pain31 (27)10 (9)1 (<1)
Febrile neutropenia31 (27)22 (19)3 (3)
Decreased appetite29 (25)2 (2)0
Hypokalemia25 (22)11 (9)3 (3)
Headache20 (17)1 (<1)0
Pneumonia20 (17)14 (12)2 (2)
Pyrexia18 (16)5 (4)0
Epistaxis15 (13)2 (2)0
Hypomagnesemia15 (13)2 (2)0
Anemia14 (12)6 (5)4 (3)
Thrombocytopenia15 (13)3 (3)9 (8)
Hypotension14 (12)5 (4)0
Hypocalcemia14(12)5 (4)0
Asthenia13 (11)1 (<1)0
Constipation13 (11)1 (<1)0