Table 4.

Treatment-related abnormal hematology laboratory values by dosea

Urelumab dose
0.1 mg/kg (n = 61)b0.3 mg/kg (n = 56)b≥1 mg/kg (n = 229)b
Absolute neutropenia, n (%)
 Total grade 1–414 (23)19 (34)64 (28)
 Grade 16 (10)9 (16)28 (12)
 Grade 23 (5)3 (5)13 (6)
 Grade 32 (3)3 (5)7 (3)
 Grade 43 (5)4 (7)16 (7)
Thrombocytopenia, n (%)
 Total grade 1–412 (20)25 (45)63 (28)
 Grade 17 (11)24 (43)46 (20)
 Grade 23 (5)07 (3)
 Grade 31 (2)07 (3)
 Grade 401 (2)3 (1)
Leukopenia, n (%)
 Total grade 1–410 (33)19 (34)84 (37)
 Grade 113 (21)8 (14)50 (22)
 Grade 22 (3)5 (9)15 (7)
 Grade 34 (7)4 (7)14 (6)
 Grade 41 (2)2 (4)5 (2)
  • aData from the 344 patients; data not available from two patients who received urelumab ≥1 mg/kg.

  • bPatients received urelumab every 3 weeks, except 40 patients from study -006 who received 1 mg/kg every 6 weeks.