Table 3.

Treatment-related abnormal LFT laboratory values by dosea

Urelumab dose
0.1 mg/kg (n = 61)b0.3 mg/kg (n = 56)b≥1 mg/kg (n = 229)b
ALT, n (%)
 Total grade 1–419 (31)28 (50)135 (59)
 Grade 118 (30)21 (38)63 (28)
 Grade 21 (2)3 (5)28 (12)
 Grade 303 (5)27 (12)
 Grade 401 (2)17 (7)
AST, n (%)
 Total grade 1–423 (38)29 (52)136 (59)
 Grade 122 (36)21 (38)79 (34)
 Grade 204 (7)18 (8)
 Grade 31 (2)3 (5)29 (13)
 Grade 401 (2)10 (4)
Total bilirubin, n (%)
 Total grade 1–410 (16)3 (5)40 (18)
 Grade 110 (16)1 (2)22 (10)
 Grade 201 (2)9 (4)
 Grade 301 (2)5 (2)
 Grade 4004 (2)
  • aData are from the 346 patients who received at least one dose of urelumab.

  • bPatients received urelumab every 3 weeks, except 40 patients from study -006 who received 1 mg/kg every 6 weeks.