Table 1.

Manchester diagnostic criteria for NF2 (these include the NIH criteria with additional criteria; refs. 1, 2)

Bilateral vestibular schwannomas (VS) or family history of NF2 plus
1) Unilateral VS or
2) Any two of: meningioma, glioma,a neurofibroma, schwannoma, posterior subcapsular lenticular opacities
Additional criteria: Unilateral VS plus any two of: meningioma, glioma, neurofibroma, schwannoma, and posterior subcapsular opacities
Multiple meningioma (two or more) plus unilateral VS or any two of: glioma, neurofibroma, schwannoma, and cataract
  • NOTE: “Any two of” refers to individual tumors or cataract, not to tumor types.

  • aUsually spinal cord ependymoma.