Table 1.

Tumor and normal tissue specimens used for whole exome sequencing

IDMetastatic siteAnatomic locationDate collectedTissue preservationSourceNotes
M26Primary melanomaLeft upper arm12/31/2008FFPESurgery, no prior therapy
M23Axillary lymph nodeLeft axilla9/27/2010FFPESurgery, no prior therapy
M24SkinLeft axilla5/25/2011FFPESurgery, no prior therapy
M25SkinLeft chest wall11/5/2012FFPESurgery, post ipilimumab
M1Lymph nodeLeft axilla11/5/2013Snap frozen and FFPEAutopsyProgressing on anti–PD-1
M2Lymph nodeLeft axilla11/5/2013Snap frozen and FFPEAutopsyProgressing on anti–PD-1
M3SkinLeft chest wall11/5/2013Snap frozen and FFPEAutopsyRegressing on anti–PD-1
M4SkinLeft chest wall11/5/2013Snap frozen and FFPEAutopsyRegressing on anti–PD-1
M5SkinLeft chest wall11/5/2013Snap frozen and FFPEAutopsyRegressing on anti–PD-1
M6SkinLeft chest wall11/5/2013Snap frozen and FFPEAutopsyRegressing on anti–PD-1
M7SkinLeft chest wall11/5/2013Snap frozen and FFPEAutopsyRegressing on anti–PD-1
M8SkinLeft chest wall11/5/2013Snap frozen and FFPEAutopsyRegressing on anti–PD-1
M9SkinLeft chest wall11/5/2013Snap frozen and FFPEAutopsyProgressing on anti–PD-1
M10SkinLeft chest wall11/5/2013Snap frozen and FFPEAutopsyProgressing on anti–PD-1
M11SkinLeft chest wall11/5/2013Snap frozen and FFPEAutopsyProgressing on anti–PD-1
M12SkinLeft chest wall11/5/2013Snap frozen and FFPEAutopsyProgressing on anti–PD-1
M13Local recurrenceLeft arm surgical site11/5/2013Snap frozen and FFPEAutopsy
M14Lung11/5/2013Snap frozen and FFPEAutopsyProgressing on anti–PD-1
M15Small bowel11/5/2013FFPEAutopsyDiscovered at autopsy
M16Small bowel11/5/2013FFPEAutopsyDiscovered at autopsy
M17Small bowel11/5/2013FFPEAutopsyDiscovered at autopsy
M18Small bowel11/5/2013FFPEAutopsyDiscovered at autopsy
M19Stomach11/5/2013FFPEAutopsyDiscovered at autopsy
M20Stomach11/5/2013FFPEAutopsyDiscovered at autopsy
M21Stomach11/5/2013FFPEAutopsyDiscovered at autopsy
M22Brain11/5/2013FFPEAutopsyDiscovered at autopsy
GermlineNormal kidney11/5/2013Snap frozen and FFPEAutopsy