Table 3.

Circumstances in which surveillance recommendations should be followed

Pathogenic variant detected in cancer-predisposing gene
Clinical criteria met for a syndrome, but genetic testing not pursued
Clinical criteria met for a syndrome, but no pathogenic variant detected
50% risk (e.g., parent/sibling with syndrome), but genetic testing not (yet) pursued
50% risk (e.g., parent/sibling with syndrome), but informative genetic testing not available