Table 2.

Genotype–phenotype associations with specific RET mutations

ATA MTC risk categoryRET codonMTCPHEOPHPTCLAHD
Highest (HST)918++++++
High (H)634,++++++++
883
Moderate (MOD)All others++++/++++ (only codon 804)+ (only codons 609, 611, 618, 620)
  • NOTE: Data from Wells et al. (65). American Thyroid Association (ATA) risk categories based on RET allele: CLA, cutaneous lichen amyloidosis; HD, Hirschsprung disease; MTC, medullary thyroid carcinoma; PHEO, pheochromocytoma; PHPT, primary hyperparathyroidism.