Table 1.

Hereditary RB surveillance protocol

AgeFrequency
Surveillance for intraocular RBa
Birth to 8 weeksNonsedated exams every 2 to 4 weeks
8 weeks to 12 monthsEUA monthly
12 to 24 monthsEUA every 2 months
24 to 36 monthsEUA every 3 months
36 to 48 monthsEUA every 4 months
48 to 60 monthsEUA every 6 months
5 to 7 yearscNonsedated exams every 6 months
Surveillance for trilateral RB
Brain MRI at the time of RB diagnosis; some centers recommend a brain MRI every 6 months until 5 years old
Surveillance for second primary tumors
Education regarding second primary tumor risks and close attention to any new signs/symptoms
Skin exam by the pediatrician during well child visits, to continue annually by the primary care physician or dermatologist for melanoma from age 18
Some consider WBMRI annually after age 8, but no consensusb
  • Abbreviation: WBMRI, whole-body MRI.

    aOn the basis of consensus recommendations of the American Association of Ophthalmic Oncologists and Pathologists.

  • bOr later, when the child is able to tolerate WBMRI without anesthesia.

  • cSome suggest continuing exams every 1 to 2 years after age 7.