Table 1.

Patient characteristics of screening cohort of ALK-positive patients with advanced non-squamous NSCLC by dichotomous ALK expression levels

ALK-IHC+ALK-IHCP
No. of patients1313
Male/Female2/118/50.02
Median age (Range), years55 (21–73)61 (38–79)0.41
ECOG performance score
 0–111120.78
 210
 311
Smoking status
 Never smoker630.35
 Current smoker25
 Former smoker55
Time on crizotinib (95% CI), mo8.4 (3.1–13.7)1.5 (0.9–2.1)<0.001
  • NOTE: In 26 of 29 patients, dichotomous ALK-IHC could be performed. Available tissue blocks previously used for ALK-FISH do not contain any neoplastic cells and dichotomous ALK-IHC and could therefore not be performed in 3 patients.