Table 1.

Sensitivity and specificity of different E2 methylation cutoff levels to distinguish responders and nonresponders

Response to cidofovir and E2 methylation
Responds to treatment if E2 methylation is greater than or equal toSensitivity (%)Specificity (%)
−1.001000
0.4310015.4
0.9410023.1
1.0710030.8
1.3210038.5
1.8110046.2
2.1594.146.2
2.4194.153.8
2.8994.161.5
3.2194.169.2
3.5694.176.9
3.8788.276.9
3.9488.284.6
4.1282.484.6
4.2676.584.6
4.6270.684.6
5.0470.692.3
5.1364.792.3
5.8158.892.3
7.6858.8100
9.0152.9100
22.3647.1100
44.7341.2100
62.4435.3100
76.5129.4100
84.8423.5100
88.4817.6100
90.9211.8100
93.445.9100
95.360100
Response to imiquimod and E2 methylation
Responds to treatment if E2 methylation is less than or equal toSensitivity (%)Specificity (%)
−0.590100
0.65093.7
1.065.993.7
1.415.987.5
1.6711.887.5
1.9717.687.5
2.1923.587.5
2.2529.487.5
2.3435.387.5
2.4141.287.5
2.4747.187.5
2.5347.181.2
2.6152.981.2
2.8058.881.2
3.0958.875
3.2358.868.7
3.4058.862.5
3.6464.762.5
3.9670.662.5
5.8876.562.5
7.6482.462.5
11.6982.456.2
22.4982.450
31.0588.250
33.1788.243.7
35.9988.237.5
60.9794.137.5
85.6894.131.2
88.0594.125
88.7894.118.7
89.8310018.7
91.8210012.5
93.361006.2
  • NOTE: The level of methylation in the first column is based on the average methylation found from the multiple CpGs tested in the E2 region. The smallest cutoff value represents the minimum E2 methylation value obtained −1, and the largest cutoff point represents the maximum value +1. Cutoff values between these are the average of two consecutively ordered observed test values, generated by SPSS ROC analysis.