Table 2.

Univariate and multivariate analysis of predictors of CR and OS in the study population

Overall response
Univariate analysisMultivariable analysisa
CovariateOR (95% CI)PbOR (95% CI)P
Clinical variables
 Disease status(<0.001)
Refractory (vs. relapsed)0.2 (0.1, 0.9)0.03Not estimable
Newly diagnosed (vs. relapsed)2.1 (1.0, 4.6)0.0513.6 (1.1, 11.7)0.037
 Baseline WBC≥10 (vs. <10)0.7 (0.3, 1.5)0.390.5 (0.2, 1.8)0.292
 Cytogenetic risk(0.416)
Intermediate (vs. poor)0.6 (0.3, 1.3)0.2040.6 (0.2, 2.0)0.424
Favorable (vs. poor)1.0 (0.2, 4.9)0.9510.8 (0.1, 5.6)0.843
 Age≥70 (vs. <70)1.3 (0.7, 2.5)0.4471.3 (0.4, 3.8)0.674
 ECOG P.S.(0.98)
1 (vs. 0)1.0 (0.5, 1.9)0.921.6 (0.6, 4.4)0.395
2 (vs. 0)1.1 (0.4, 3.2)0.9021.0 (0.2, 5.8)0.981
Mutations
 STAG2 mutationPresent (vs. absent)0.2 (0.1, 0.6)0.0020.3 (0.1, 1.4)0.117
 IDH2 mutationPresent (vs. absent)0.4 (0.2, 0.9)0.0290.4 (0.1, 1.3)0.139
 NPM1 mutationPresent (vs. absent)2.5 (1.0, 6.2)0.0388.6 (1.6, 45.8)0.012
Overall survival
Median OSUnivariate analysisMultivariable analysisc
Covariate(95% CI), monthsHR (95% CI)PdHR (95% CI)P
Clinical variables
 DiagnosisMDS19.4 (11.3, 22.7)11
AML9.1 (8.0, 11.1)2.0 (1.3, 3.0)0.00082.3 (1.3, 4.3)0.007
 Baseline WBC<1011.5 (9.8, 13.6)11
≥108.8 (6.7, 10.5)1.5 (1.1, 2.0)0.01162.2 (1.4, 3.5)0.001
 Disease Status(0.0132)
Relapsed7.6 (6.4, 10.5)11
Refractory9.8 (8.3, 13.2)0.8 (0.5, 1.2)0.2181.0 (0.5, 1.8)0.976
Newly diagnosed11.7 (10.1, 14.9)0.6 (0.5, 0.9)0.0050.5 (0.3, 0.8)0.003
 ECOG P.S.(0.0235)
012.7 (9.6, 19.4)11
110.1 (8.0, 11.5)1.6 (1.1, 2.1)0.0091.6 (1.0, 2.6)0.035
29.5 (7.8, 15.4)1.5 (0.9, 2.4)0.09681.6 (0.9, 2.9)0.131
 Age<709.3 (7.6, 11.6)11
≥7011.1 (9.0, 13.5)0.8 (0.6, 1.1)0.17061.6 (0.9, 1.8)0.448
 Cytogenetic risk(0.8589)
Poor9.5 (7.1, 11.1)11
Intermediate11.4 (8.1, 15.3)0.9 (0.6, 1.3)0.63671.2 (0.7, 1.9)0.549
Favorable12.0 (1.7, N/E)0.8 (0.4, 1.8)0.63921.1 (0.5, 2.8)0.802
Mutations
 CDKN2A mutationAbsent11.0 (9.3, 12.6)11
Present4.5 (0.2, 7.8)3.9 (1.9, 8.0)0.000110.0 (3.3, 30.3)<0.001
 TP53 mutationAbsent11.3 (9.4, 13.0)11
Present7.6 (2.4, 9.6)1.8 (1.2, 2.6)0.0034.7 (2.5, 9.0)<0.001
 IDH1 mutationAbsent11.1 (9.4, 12.7)11
Present5.6 (2.8, 9.8)1.9 (1.2, 2.9)0.0043.6 (1.7, 7.6)0.001
 NPM1 mutationAbsent11.1 (9.1, 12.6)11
Present8.1 (5.6, 10.7)1.5 (1.0, 2.2)0.0370.6 (0.4, 1.1)0.122
 FLT3ITD mutationAbsent11.1 (9.0, 12.7)11
Present8.8 (6.1, 11.6)1.5 (1.0, 2.1)0.041.0 (0.6, 1.8)1
  • Abbreviations: ECOG P.S., Eastern Cooperative Oncology Group Performance Status; N/E, not estimable values in brackets refer to P value of the overall test for the specified variable; WBC, white blood cell.

  • aLogistic regression model adjusted for all variables in the table.

  • bGiven by the Chi-square or Fisher exact test, corresponding to pairwise comparisons or the overall comparison as indicated between parentheses.

  • cCox proportional hazards model adjusted for all variables in the table.

  • dGiven by the log-rank test, corresponding to pairwise comparisons, or the overall comparison as indicated between parentheses.