Table 3.

Treatment-related adverse events grades 3 and 4

Course 1 (n = 13)Course 2 (n = 11)Course 3 (n = 11)Course 4 (n = 10)Course 5 (n = 9)Course 6 (n = 8)
GradesGradesGradesGradesGradesGrades
Toxicity343434343434
Nonhematologic
 Acidosis11
 Alanine aminotransferase elevated311
 Anaphylaxis1
 Aspartate aminotransferase elevated21
 Diarrhea2
 Febrile neutropenia1181275
 Fever2
 Increased GGT2
 Hypocalcemia1
 Hypokalemia3132
 Hyponatremia11
 Hypophosphatemia122
 Infections and infestations - Other1
 Myelodysplastic syndrome1
 Nausea/vomiting112
 Pain111
 Weight Loss1
Hematologic
 Anemia1211617818
 Leukopenia1311422498
 Lymphopenia31011332398
 Neutropenia1311332398
 Thrombocytopenia13110133398