Table 3.

Pharmacokinetic parameters after a single dose of seviteronel

TreatmentAUC0–24 (h/ng/mL)AUCINF (h/ng/mL)CL/F (L/h)Cmax (ng/mL)Tmax (h)Cmin (ng/mL)T1/2 (h)
600 mg + DT (n = 2)31,702 ± 12,978a44,049 ± 013.6b4,515 ± 1,7041.0 ± 0.02370 ± 43.416.8b
600 mg QD (n = 7)30,410 ± 7,12637,668 ± 6,26716.3 ± 3.04,403 ± 1,8172.8 ± 2.5376 ± 1489.2 ± 2.1
750 mg QD (n = 8)34,445 ± 13,43244,422 ± 8,36917.4 ± 3.03,809 ± 2,2385.1 ± 7.8562 ± 3648.1 ± 2.4
900 mg QD (n = 1)79,824bNCNC5,600b4.0b2070bNC
  • Abbreviations: AUC0–24, AUC from the time of dosing 0–24 hours; AUCINF, AUC from the time of dosing extrapolated to infinity; CL/F, apparent clearance; Cmax, maximum concentration; Cmin, minimum concentration; DT, dose titration; NC, not calculated; QD, once daily; Tmax, time of maximum observed concentration; T1/2, terminal half-life.

  • aMean ± SD.

  • bn = 1