Table 1.

Summary of clinical characteristics of the cohort

RECIST response
VariablePD (N = 44)SD + PR (N = 33)Total (N = 77)P
Gender, no. (%)Female12 (27)6 (18)18 (23)0.51
Male32 (73)27 (82)59 (77)
Age, yearsMedian (range)64 (45–85)68 (51–85)66 (45–85)0.01
Mean (SD)64.2 (8.4)69.4 (9.0)66.4 (9.0)
Smoker, no. (%)No4 (9)3 (9)7 (9)1.00
Yes40 (91)30 (91)70 (91)
WHO performance status, no. (%)015 (34)17 (52)32 (42)0.19
1–229 (66)16 (48)45 (58)
Histology, no. (%)Nonsquamous cell25 (57)19 (58)44 (57)0.97
Squamous cell18 (41)12 (36)30 (39)
Other1 (2)2 (6)3 (4)
Stage, no. (%)IIIB4 (9)6 (18)10 (13)0.31
IV40 (91)27 (82)67 (87)
EGFR, no. (%)Not mutated40 (91)31 (94)71 (92)0.70
Mutated4 (9)2 (6)6 (8)
KRAS, no. (%)Not mutated25 (76)18 (78)43 (77)1.00
Mutated8 (24)5 (22)13 (23)
ALK, no. (%)Not mutated31 (100)19 (95)50 (98)
Mutated0 (0)1 (5)1 (2)
Not evaluated131326
PD-L1 expression (Sp142), no. (%)Low27 (64)16 (48)43 (57)0.26
High15 (36)17 (52)32 (43)
Not evaluated202