Table 1.

Prostate cancer biology and androgen receptor–signaling targeted drugs

AR signaling pathwayTherapeutic strategiesDrugs in development
Androgen productionCYP17 inhibitorsKetoconazole
Abiraterone
TAK-700
Androgen transportBlock transportHE-3235
AR bindingNovel AR inhibitorsMDV3100
ARN-509

NOTE. As discussed above, an incomplete response to ADT and subsequent disease progression might be mediated by continued AR signaling. Different approaches can target continued AR signaling and are being investigated in clinical trials.