Table 4.

Effect of the timing of the last systemic therapy before tumor harvest on the success rate of the initial TIL outgrowth and TL/fragment

CategoryNumber of samplesSamples with >40 × 106 TILPa (versus no previous therapy)Mean TIL/fragment (×106)Pb (versus no previous therapy)
Biochemotherapy
 Day 0–3091 (11)c0.00093.280.006
 Day 31–60102 (20)0.0033.100.006
 Day 61–9032 (67)1.05.940.48
 >90 days108 (80)0.7211.260.77
IL-2
 Day 0–3074 (57)0.437.360.30
 Day 31–6064 (67)1.019.250.77
 Day 61–9043 (75)1.07.990.59
 >90 days96 (67)1.013.960.97
Other immunotherapy
 Day 0–3052 (40)0.173.080.08
 Day 31–6086 (75)1.026.790.51
 Day 61–9053 (60)0.6318.470.90
 >90 days2919 (66)0.6417.750.64
Chemotherapy
 Day 0–301913 (68)1.011.850.40
 Day 31–60138 (62)0.525.840.06
 Day 61–9084 (50)0.255.020.12
 >90 days84 (50)0.2513.940.71
  • aFisher's exact test was used. P values below 0.05 are in bold.

  • bWilcoxon rank-sum test or Kruskal–Wallis test was used.

  • cNumbers in parentheses indicate percentage successful TIL growers based on total number in that group shown in the Number of samples column.