Table 2

Association of the expression of matrix metalloproteinase (MMP)-2 and -9, membrane-type 1 (MT1)- and -type 2 (MT2)-MMP, and their tissue inhibitors (TIMP-1, -2, and -3) with each other in 83 patients with classical and 18 with desmoplastic medulloblastoma (MB)

Total (n)MMP-2, n (%)MMP-9, n (%)MT1-MMP, n (%)MT2-MMP, n (%)TIMP-1, n (%)TIMP-2, n (%)TIMP-3, n (%)
Classical MB (n = 83)
 MMP-2
  +3125 (81)28 (90)26 (84)14 (45)14 (45)24 (77)
  −5237 (71)34 (65)a37 (71)9 (17)b20 (38)32 (62)
 MMP-9
  +6250 (81)47 (76)19 (31)25 (40)49 (79)
  −2112 (57)16 (76)4 (19)9 (43)7 (33)b
 MT1-MMP
  +6250 (81)21 (34)29 (47)47 (76)
  −2113 (62)2 (10)5 (24)9 (43)b
 MT2-MMP
  +6320 (32)28 (44)46 (73)
  −203 (15)6 (30)10 (50)a
 TIMP-1
  +2312 (52)20 (87)
  −6022 (37)36 (60)
 TIMP-2
  +3427 (79)
  −4929 (59)
Desmoplastic MB (n = 18)
 MMP-2
  +33 (100)3 (100)3 (100)03 (100)2 (67)
  −1512 (80)12 (80)15 (100)012 (80)4 (27)
 MMP-9
  +1513 (87)15 (100)012 (80)6 (40)
  −32 (67)3 (100)03 (100)0
 MT1-MMP
  +1515 (100)013 (87)6 (40)
  −33 (100)02 (67)0
 MT2-MMP
  +18015 (83)6 (33)
  −0000
 TIMP-1
  +000
  −1815 (83)6 (0)
 TIMP-2
  +156 (40)
  −30
  • a,b Pearson’s χ2 test was used to assess the significance of the association of the expression of the different proteins in classical medulloblastoma:

  • a P < 0.05;

  • b P < 0.005.