Table 2

Aberrant promoter methylation distribution in benign breast lesions

CasesESR1CDH1TRβ 1GSTP1CCND2BRCA1RARβ2APCp16HIC1Histopathology
4583MPUPMPUPUPUPUPUPMPMPFCD
4176MPUPUPUPUPUPUPMPUPMPFCD+FAd
4171MPUPUPUPUPUPUPUPUPMPFCD+DP+ADHy
3744MPUPUPUPUPUPUPUPUPUPFCD
3746UPUPUPUPUPMPUPUPUPUPFad
4750UPUPUPUPUPMPUPUPUPUPFCD+FAd
5560UPUPUPUPUPUPUPUPMPUPFAd
3731UPUPUPUPUPUPUPUPUPUPFCD
3967UPUPUPUPUPUPUPUPUPUPFCD
5366UPUPUPUPUPUPUPUPUPUPFad
Unmethylated61091010810987
Methylated4000020123
%*40%0%10%0%0%20%0%10%20%30%
  • Abbreviations: MP, methylated promoter; UP, unmethylated promoter; FCD, fibrocistic disease; FAd, fibroadenoma; DP, ductal papilloma; ADHy, atypical ductal hyperplasia.

  • * Percentage of tumors that carry methylation at the particular gene.