Table 3

Impact of individual immunomarkers on cluster group determination (χ2 test results)

Markern (within the tissue arrays)Distribution of the results by cluster groupsP
Cluster group 1Cluster group 2Cluster group 3
ER, positive 202/253194/194 (100%)2/8 (25%)6/51 (11.8%) <0.001
PR, positive 162/265151/200 (75.5%)2/10 (20%)9/55 (16.3%) <0.001
CK5/6, positive 44/25414/191 (7.3%)4/9 (44.4%)26/54 (48.2%) <0.001
p63, positive 34/26017/195 (8.7%)4/9 (44.4%)13/56 (23.3%) <0.001
YB1, strongly positive116/26282/196 (41.9%)5/10 (50%)29/56 (51.7%)0.8
CD10, strongly positive84/23956/140 (40%)3/9 (33.3%)25/51 (49%)0.4
IGFBP5, strongly positive94/26568/199 (34.2%)6/10 (60%)20/56 (35.7%)0.7
IGFBP2, strongly positive129/26399/263 (50.2%)6/10 (60%)24/54 (42.8%)0.5
CD117 (mast cell), positive 57/26146/199 (23.6%)9/10 (90%)2/56 (3.6%) <0.001
PTEN, negative 35/26023/197 (11.7%)0/9 (0%)12/54 (22.2%) 0.02
TIP1, strongly positive 12/2325/176 (2.8%)0/10 (0%)7/47 (14.9%) <0.001
Ki67, positive 82/26335/197 (17.7%)4/10 (40%)45/56 (82.3%) <0.001
CA IX, positive 49/26514/200 (7%)1/10 (10%)34/55 (61.8%) <0.001
NSE, positive12/26111/195 (5.6%)1/10 (10%)0/56 (0%)0.5
Relaxin, positive218/259163/194 (84%)9/10 (90%)46/55 (83.7%)0.3
Cox2, strongly positive103/26177/198 (38.9%)6/8 (75%)20/55 (36.4%)0.1
p53, positive 38/24812/186 (6.4%)4/10 (40%)22/52 (42.3%) <0.001
Her3, strongly positive37/25028/189 (14.8%)5/10 (50%)27/51 (42.9%)0.6
Her2, strongly positive 30/25712/192 (6.3%)4/10 (40%)14/55 (21.4%) <0.001
  • NOTE. Bold font has been used for markers that contributed significantly to cluster group designation, and their respective P values (P < 0.05).