Table 1

Patient characteristics at baseline

DL 1 (450 mg daily) (n = 3)DL 2 (900 mg daily) (n = 3)DL 3 (1.8 g daily) (n = 3)DL 4 (3.6 g daily) (n = 6)
Sex
 Male0113
 Female3223
Age (years)
 Mean69686556
 Range68–7066–7055–7450–64
WHO performance
 01112
 12224
Sites of measurable disease
 Colorectum1001
 Liver3336
 Lung1112
 Peritoneum1000
 Other0121
Previous chemotherapy
 5-Fluorouracil3336
 Irinotecan1224
 Oxaliplatin0113
 Other1214
Previous radiotherapy1103
Previous surgery3336
NSAID stopped for trial1101
CEA > 9 μg/L2326
CEA > 500 μg/L1214
CA 19.9 > 37 ku/L2325
CA 125 > 35 iu/L0011
  • Abbreviations: NSAID, non-steroidal anti-inflammatory drug; CEA, carcinoembryonic antigen; DL, dose level.