Table 2

Influences of several cofactors on H-RFS: univariate analysis

VariableCases (N = 134)Metastasis rate (%)HR (95% CI)P value (Log-rank test)
Location
 Colon7014 (20)Referent
 Rectum6417 (27)1.40 (0.69–2.83)NS
Tumor size
 ≤5 cm7316 (22)Referent
 >5 cm6115 (25)1.13 (0.56–2.29)NS
Histologic type
 W/D & M/D12027 (23)Referent
 Others144 (29)1.40 (0.45–4.89)NS
Depth
 Serosa negative607 (12)Referent
 Serosa positive7424 (32)3.27 (1.42–5.80)0.003
Lymph vessel invasion
 Absent639 (14)Referent
 Present7122 (31)2.39 (1.12–4.58)0.023
Venous invasion
 Absent292 (7)Referent
 Present10529 (28)4.69 (1.17–6.03)0.020
IGF-1R expression
 Diffuse positive404 (10)Referent
 Focal positive9427 (28)3.21 (1.14–5.16)0.021
  • Abbreviations: W/D, well differentiated; M/D, moderately differentiated; HR, hazard ratio; CI, confidence interval; NS, not significant.