Table 1

Patient’s characteristics

n
Patients13
Male/Female10/3
Age, years
 Median60
 Range45–71
ECOGa performance status
 08
 15
Primary
 Colon9
 Rectum4
Previous surgery on primary tumor13
Number of metastatic sites
 Single2
 Multiple11
Sites of disease
 Liver12
 Lung6
 Abdomen6
 Other1
Liver involvement
 <25%4
 25–50%6
 >50%2
Previous chemotherapy
 5-FU/LV bolus6
 5-FU c.i.4
 5-FU/LV bolus and 5-FU c.i.1
 Reltitrexed2
Previous radiotherapy4
CEA, ng/ml
 Median19
 Range(4.5–720)
Courses administered63
Courses/patient
 Median5
 Range1–8
  • a ECOG, Eastern Cooperative Oncology Group; CEA, carcinoembryonic antigen; c.i., continuous infusion; 5-FU, 5-fluorouracil; LV, leucovorin.