Table 3

Relationship between clinical variables and expression of ABCa transporter proteins

nPgp Positive patients (%)MRP1 Positive patients (%)MRP2 Positive patients (%)MRP3 Positive patients (%)BCRP Positive patients (%)
Total7225 (35)56 (78)12 (17)10 (14)33 (46)
Gender
 Male4913 (27)b38 (78)9 (22)9 (18)26 (53)
 Female2312 (52)18 (78)3 (4)1 (5)7 (30)
Histology
 Sq182 (11)c12 (67)2 (11)2 (11)7 (39)
 Non-sq5423 (43)44 (81)10 (19)8 (15)26 (48)
Stage
 IIIB328 (25)23 (72)0 (0)d5 (16)12 (38)
 IV4017 (43)33 (83)12 (30)5 (13)21 (53)
PS
 071 (14)4 (57)1 (14)0 (0)3 (43)
 16524 (37)52 (80)11 (17)10 (15)30 (46)
Smoking history
 Positive5416 (30)41 (76)10 (20)8 (15)28 (52)
 Negative189 (50)15 (83)2 (6)2 (10)5 (28)
  • a ABC, ATP-binding cassette; Pgp, P-glycoprotein; MRP, multidrug resistance protein; Sq, squamous; PS, performance status.

  • b P = 0.03.

  • c P = 0.02.

  • d P = 0.0007.