Table 3

Estimated odds ratios for individual morphological features in BRCA1 and BRCA2 tumor versus control

FactorLevelBRCA1BRCA2
ORa95% CIOR95% CI
Borderline(vs. invasive)0.0440.015–0130.570.15–2.21
χ12 = 33.61P < 0.0001χ12 = 0.67
Histological type (vs. all other types)Serous1.841.21–2.791.720.85–3.51
Mucinous0.130.05–0.340.560.06–1.90
Endometrioid0.780.52–1.160.870.42–1.81
Clear cell0.770.45–1.300.510.20–1.27
Giant cells2.611.17–5.822.240.06–1.93
Histological type (one type only)Serous1.01.0
Mucinous0.100.03–0.310.180.02–1.43
Endometrioid0.650.39–1.060.690.28–1.73
Clear cell0.590.28–1.220.240.0.05–1.13
χ32 = 16.95P = 0.0007χ32 = 4.28
Psammoma bodiesPresent1.150.68–1.940.950.38–2.35
χ12 = 0.27χ32 = 0.03
GradeWell1.01.0
Moderately5.982.12–16.881.040.21–5.06
Poorly10.303.59–29.63.200.73–14.01
Undifferentiated15.444.74–50.411.922.41–59.0
χ12 = 20.34P < 0.0001χ12 = 4.80P = 0.028
χ32 = 23.83P < 0.0001χ32 = 18.22P = 0.0001
Solid componentAbsent1.01.0
<25%1.710.98–2.971.070.26–4.36
25–75%2.621.43–4.802.520.61–10.43
>75%3.641.78–7.436.781.65–27.86
χ12 = 12.55P = 0.004χ12 = 3.64P = 0.056
χ32 = 13.77P = 0.001χ32 = 13.06P = 0.0014
Vascular invasionPresent1.020.67–1.560.470.20–1.10
χ12 = 0.02χ12 = 3.00P = 0.08
NecrosisNone1.01.0
Focal0.940.61–1.451.260.61–2.61
Moderate0.800.46–1.391.270.48–3.33
Marked1.160.59–2.262.110.68–6.51
χ12 = 0.00χ32 = 1.53χ12 = 1.32χ32 = 1.70
Mitotic count<101.01.0
10–191.200.66–2.160.270.02–2.96
20–291.860.96–3.592.780.54–14.2
30–390.820.42–1.603.640.68–19.6
40+1.370.74–2.515.061.05–24.3
χ12 = 0.59P = 0.049χ12 = 2.01P = 0.16
χ42 = 7.84χ42 = 10.91P = 0.012
  • a OR, odds ratio; CI, confidence interval.