Table 1

MTDa of chemotherapeutic agents alone and in combination with MSC (0.2 mg/mouse/day)

DrugScheduleMTD (mg/kg)
− MSC+ MSCb
Irinotecani.v. weekly × 4100200
FUi.v. weekly × 4100125
Irinotecan + FUi.v. weekly × 450 (each)ND
Oxaliplatini.v. weekly × 47.512.5
Cisplatini.v. × 1815
Taxoli.v. × 13575
Doxorubicini.v. × 11012.5
  • a MTD, maximum tolerated dose; MSC, methylselenocysteine; FU, 5-fluorouracil; ND, not determined.

  • b For the combination, MSC was administered p.o. 7 days before therapy in total 28 days for the weekly × 4 schedule and 14 days for the i.v. × 1 schedule.