Table 3

Association between clinical, histopathological, and immunohistochemical variables and outcome during follow-up

ParameterOverall survivalDeath from diseaseOnly metAll metDisease-free survival
Clinical
    Sex0.99 (0.35, 0.010, 0.51)0.75 (0.65, 0.032, 0.51)0.83 (0.30, 0.08, 0.69)0.99 (0.48, 0.09, 0.56)0.82 (0.45, 0.06, 0.90)
    Depth, not s.c.0.065 (0.09, 0.15, 0.94)0.005 (0.003, 0.19, 0.94)0.006 (0.008, 0.46, 0.48)0.006 (0.002, 0.48, 0.83)0.003 (0.002, 0.41, 0.67)
    Size ≤ 6 cm0.0017 (0.006, 0.46, 0.39)0.00016 (0.0002, 0.61, 0.39)0.00002 (0.00008, 0.41, 0.18)0.00045 (0.0006, 0.50, 0.36)0.00005 (0.00005, 0.43, 0.37)
    >11 cm0.0005 (0.002, 0.87, 0.087)0.0001 (0.0004, 0.68, 0.087)0.00005 (0.0006, 0.68, 0.016)0.00013 (0.0007, 0.74, 0.07)0.00015 (0.001, 0.58, 0.02)
    Intralesional surgery0.033 (0.049, 0.49, 0.72)0.039 (0.017, 0.47, 0.72)0.73 (0.11, NS, 0.76)0.1 (0.053, 0.92, 0.65)0.17 (0.10, 0.99, 0.97)
Histopathological
    Malignancy grade 40.33 (0.20, 0.77, 0.77)0.48 (0.44 0.96, 0.77)0.73 (0.96, 0.56, 0.48)0.75 (0.69, 0.53, 0.74)0.96 (0.70, 0.43, 0.65)
    Presence of necroses0.029 (0.24, 0.04, 0.27)0.025 (0.17, 0.066, 0.27)0.024 (0.27, 0.047, 0.11)0.06 (0.27, 0.042, 0.32)0.01 (0.16, 0.03, 0.13)
    Mitotic count > 2 per HPF0.005 (0.002, 0.95, 0.19)0.017 (0.008, 0.93, 0.19)0.073 (0.13, 0.56, 0.047)0.023 (0.009, 0.56, 0.17)0.11 (0.30, 0.47, 0.055)
    Infiltrative growth pattern0.31 (0.36, 0.54, 0.74)0.4 (0.52, 0.52, 0.74)0.33 (0.20, 0.43, 0.73)0.57 (0.61, 0.44, 0.79)0.21 (0.27, 0.38, 0.71)
    Vascular invasion0.33 (0.42, NS, 0.63)0.6 (0.69, NS, 0.63)0.92 (0.64, NS, 0.59)0.82 (0.90, NS, 0.72)0.68 (0.92, NS, 0.32)
Immunohistochemical
    Ki-67 > 10% positive cells0.19 (0.30, 0.84, 0.20)0.36 (0.42, 0.95, 0.20)0.89 (0.89, 0.81, 0.17)0.42 (0.57, 0.081, 0.23)0.55 (0.77, 0.66, 0.07)
    p53 ≤ 40% positive cells0.15 (0.33, 0.18, 0.40)0.34 (0.68, 0.27, 0.40)0.6 (0.53, 0.43, 0.33)0.6 (0.77, 0.43, 0.35)0.73 (0.90, 0.37, 0.37)
    p27 > 30% positive cells0.49 (0.83, 0.29, 0.48)0.55 (0.85, 0.41, 0.48)0.75 (0.75, 0.47, 0.91)0.37 (0.79, 0.72, 0.38)0.97 (0.70, 0.69, 0.83)
    Bcl-2 > 30% positive cells0.49 (0.51, 0.40, 0.83)0.42 (0.48, 0.38, 0.83)0.16 (0.21, 0.72, 0.84)0.35 (0.42, 0.67, 0.88)0.27 (0.15, 0.73, 0.55)
    Vessel density ≤ 30 vessels per HPF0.023 (0.21, 0.22, 0.14)0.037 (0.24, 0.27, 0.14)0.12 (0.62, 0.38, 0.23)0.64 (0.40, 0.40, 0.10)0.09 (0.51, 0.34, 0.11)
    IGF-1R ≤ 50% positive cells0.023 (0.47, 0.12, 0.058)0.02 (0.31, 0. 21, 0.058)0.093 (0.98, 0.23, 0.016)0.044 (0.41, 0.2, 0.06)0.11 (0.76, 0.18, 0.053)
  • NOTE: Ps were calculated with log-rank test from the difference between the curves in the Kaplan-Meier survival plot.

    Figures in the columns represent All tumors (MFH, liposarcoma, and non-MFH/liposarcoma).

  • Abbreviation: HPF, high power field; NS, not significant.