Table 5.

Epratuzumab serum pharmacokinetics

InfusionPeak (μg/mL)* n (mean ± SD)Trough (μg/mL) n (mean ± SD)Half-life (h) n (mean ± SD)
116 (40.8 ± 16.6)012 (107 ± 23)
216 (52.3 ± 16.6)16 (12.3 ± 6.0)12 (211 ± 152)
312 (64.5 ± 19.2)12 (26.3 ± 11.2)8 (211 ± 121)
45 (65.4 ± 14.7)5 (28.2 ± 8.0)4 (334 ± 94)
  • NOTE: n specifies number of patients evaluated.

  • * Serum sample obtained 2 hours after infusion.

  • Serum sample obtained immediately before infusion.

  • Half-lives determined by monoexponential fit to postinfusion serum samples.