Table 3.

Drug-related adverse effects at all dose levels for the 7-day every 3 weeks schedule (n = 9)

Adverse effectGrade 1/2, n (%)Grade 3/4, n (%)Total, n (%)
Nausea and/or vomiting3 (33)1 (11)4 (44)
Diarrhea3 (33)03 (33)
Constipation3 (33)03 (33)
Abdominal pain1 (11)01 (11)
Dizziness1 (11)01 (11)
Somnolence2 (22)02 (22)
Peripheral neuropathy2 (22)02 (22)
Bone pain1 (11)01 (11)
Pruritus1 (11)01 (11)
Hepatic*2 (22)1 (11)3 (33)
Anorexia2 (22)02 (22)
Fatigue1 (11)01 (11)
  • * Increased alkaline phosphatase and/or bilirubin.