Table 4.

Drug-related adverse effects at all dose levels for the 21-day every 4 weeks schedule (n = 23)

Adverse effectGrade 1/2, n (%)Grade 3/4, n (%)Total, n (%)
Nausea and/or vomiting13 (56)013 (56)
Diarrhea9 (39)09 (39)
Constipation10 (43)010 (43)
Small bowel obstruction01 (4)1 (4)
Abdominal pain3 (13)03 (13)
Dysphagia1 (4)01 (4)
Dizziness1 (4)01 (4)
Somnolence1 (4)01 (4)
Peripheral neuropathy4 (17)04 (17)
Bone pain3 (13)03 (13)
Muscle weakness1 (4)01 (4)
Hepatic*3 (13)03 (13)
Renal1 (4)01 (4)
Dry skin1 (4)01 (4)
Rash1 (4)01 (4)
Mucositis3 (13)03 (13)
Anorexia6 (26)06 (26)
Fatigue4 (17)04 (17)
Weight loss3 (13)03 (13)
  • * Increased alkaline phosphatase, bilirubin, and/or transaminases.

  • Increased creatinine.