Table 5.

CEC phenotypic analysis

VariableNormal (n = 19)
Leukemia/MDS, baseline (n = 23)
Leukemia/MDS, treated* (n = 23)
Mean ± SEMedianMean ± SEMedianMean ± SEMedian
CEC (cells/μL, range)4.4 ± 0.3 (1.1-11.2)4.039.3 ± 27.3 (0.4-599.7)2.652.9 ± 43.1 (0.1-846.4)4.0
EPC§ (%, range)10.4 ± 0.4 (4.4-29.7)10.024.8 ± 4.7 (1.3-93.8)18.522.8 ± 5.0 (4.1-96.2)16.5
Apoptotic CEC§ (%, range)65.5 ± 0.7 (49.1-78.4)68.837.9 ± 4.4 (0.4-73.9)37.532.9 ± 4.2 (1.7-71.9)35.1
  • * Measurements in the treated group were done on cycle 1, d 21 (similar readings were obtained throughout treatment course, with variations of less than ±2/μL or ±2%).

  • Mean is distorted by 2 very large CEC concentrations.

  • P = 0.037 for refractory malignancies versus normal controls.

  • § Expressed as percentage of total CECs.

  • P < 0.0001 for refractory malignancies versus normal controls.