Table 4.

Overrepresented ontologies of genes differentially expressed in AIPC

Gene symbolFold changeDescriptionParametric PProbe setGene ontology or relationship to IL-6
ST3GALVI3.44α2,3-Sialyltransferase0.0045213355_atPB, MB
LUC7A2.75Cisplatin resistance–associated overexpressed protein0.0007220044_x_atRC
SF3B12.04Splicing factor 3b, subunit 1, 155 kDa0.0013201071_x_atRC
KIAA09701.92KIAA0970 protein0.0031202304_atRC, SCR
PNAS41.92CGI-146 protein0.0003212371_atRC, R
SFRS111.91Splicing factor, arginine/serine–rich 110.0035200685_atRC
HNRPH31.73Heterogeneous nuclear ribonucleoprotein H3 (2H9)0.0011208990_s_atRC
PTMA1.59Prothymosin, α (gene sequence 28)0.0017200773_x_atRC, SCR
UBE3A1.57Ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome)0.0014211575_s_atPB
SFRS71.56Splicing factor, arginine/serine-rich 7, 35 kDa0.0044201129_atRC
FLJ102831.51Hypothetical protein FLJ102830.0022218534_s_atRC
EIF4EL30.73Eukaryotic translation initiation factor 4E-like 30.0027213571_s_atPB
NMT20.72N-myristoyltransferase 20.0043215069_atPB
COPS60.72COP9 subunit 6 (MOV34 homologue, 34 kDa)0.0032213504_atPB
KIAA07590.71KIAA0759 protein0.002236865_atPB, RC
MRP630.66Mitochondrial ribosomal protein 630.0039221995_s_atSCR
MRPL200.65Mitochondrial ribosomal protein L200.0002220526_s_atRC, SCR, PB
HNRPA00.65Heterogeneous nuclear ribonucleoprotein A00.0007201055_s_atRC
EIF3S90.65Eukaryotic translation initiation factor 3, subunit 9, η, 116 kDa0.0001203462_x_atPB
RPL340.65Ribosomal protein L340.0010200026_atRC, SCR, PB
RPL390.63Ribosomal protein L390.0015208695_s_atRC, SCR, PB
RPL360.60Ribosomal protein L360.0045219762_s_atRC. SCR, PB
RPS210.55Ribosomal protein S210.0028200834_s_atRC, SCR, PB
RPS140.53Ribosomal protein S140.0006208646_atRC, SCR, PB
RPL35A0.53Ribosomal protein L35a0.0029213687_s_atRC, SCR, PB
MRP630.51Mitochondrial ribosomal protein 630.0009204386_s_atSCR
0.50Similar to 40S ribosomal protein S180.0023201049_s_atRC, SCR, PB
RPS160.45Ribosomal protein S160.0046213890_x_atRC, SCR, PB
RPS290.40Ribosomal protein S290.0018201094_atRC, SCR, PB
GADD45B0.28Growth arrest and DNA damage-inducible, β0.0031207574_s_atRC, SCR, PB
GADD45G0.23Growth arrest and DNA damage-inducible, γ0.0001204121_atRC, SCR, PB
VWF4.63von Willebrand factor0.0014202112_atECM, CAMA
CSPG23.10Chondroitin sulfate proteoglycan 2 (versican)0.0010204619_s_atECM
CDH113.10Cadherin 11, type 2, OB-cadherin (osteoblast)0.0004207173_x_atCAMA
LAMB13.01Laminin, β10.0047201505_atECM, CAMA
ASPN2.87Asporin (LRR class 1)0.0017219087_atECM
FN12.72Fibronectin 10.0007211719_x_atECM, CAMA
COL15A12.67Collagen, type XV, α10.0006203477_atECM, CAMA
PECAM12.62Platelet/endothelial cell adhesion molecule (CD31)0.0001208982_atCAMA
FLJ207362.46Hypothetical protein FLJ207360.0022218244_atECM
COL5A22.30Collagen, type V, α20.0043221729_atECM
SPARC2.29Secreted protein, acidic, cysteine-rich (osteonectin)0.0045212667_atECM
ECM22.25ECM protein 2, female organ and adipocyte specific0.0040206101_atECM
THBS12.18Thrombospondin 10.0038201108_s_atECM, CAMA
LAMA42.13Laminin, α40.0040202202_s_atECM, CAMA
LTBP21.61Latent transforming growth factor-β binding protein 20.0050204682_atECM
GNE0.67UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase0.0027205042_atCAMA
ICAM30.60Intercellular adhesion molecule 30.0043204949_atCAMA
CD840.58CD84 antigen (leukocyte antigen)0.0032211189__x__atCAMA
BAIAP20.40BAI1-associated protein 20.0012209502_s_atCAMA
IL60.62Interleukin-6 (IFN, β2)0.0034205207_at
JAK12.30Janus kinase 1 (a protein tyrosine kinase)0.0009201648_atSignal transduction (27)
STAT5B0.71Signal transducer and activator of transcription 5B0.0001212550_atSignal transduction (27)
JUNB0.45junB proto-oncogene0.0035201473_atGene expression (31)
JUND0.39junD proto-oncogene0.0002203752_s_atGene expression (31)
MCL10.48Myeloid cell leukemia sequence 1 (BCL2-related)0.0005200797_s_atGene expression (30)
SDC23.13Syndecan-2 (heparan sulfate proteoglycan 1, cell surface–associated, fibroglycan)0.0008212158_atGene expression (32)
LUC7A2.75Cisplatin resistance–associated overexpressed protein0.0007220044_x_atChemosensitivity (67)
KLK20.53Kallikrein-2, prostatic0.0011210339_s__atAR activation (33)
KLK30.29Kallikrein-3 (prostate-specific antigen)0.0006204582_s_atAR activation (68)
GADD45B0.26Growth arrest and DNA-damage inducible, β0.0031207574_s_atAR activation (33)
GADD45G0.23Growth arrest and DNA-damage inducible, γ0.0001204121_atAR activation (33)
  • Abbreviations: RC, ribonucleoprotein complex; PB, protein biosynthesis; MB, macromolecule biosynthesis; R, ribosome; SCR, structural constituent of ribosome; CAMA, cell adhesion molecule activity.