Table 4A.

Empirical power as a function of total sample size

TestPower (%)
N1 = N2 = 150
    Overall 0.05 level40.0
    Overall 0.04 level36.3
    Sensitive subset 0.01 level37.8
    Overall adaptive signature design60.5
N1 = N2 = 200
    Overall 0.05 level49.5
    Overall 0.04 level45.4
    Sensitive subset 0.01 level75.8
    Overall adaptive signature design85.7
N1 = N2 = 250
    Overall 0.05 level61.8
    Overall 0.04 level56.8
    Sensitive subset 0.01 level93.2
    Overall adaptive signature design96.2
N1 = N2 = 300
    Overall 0.05 level63.8
    Overall 0.04 level58.2
    Sensitive subset 0.01 level98.1
    Overall adaptive signature design99.0
N1 = N2 = 400
    Overall 0.05 level74.4
    Overall 0.04 level70.8
    Sensitive subset 0.01 level99.7
    Overall adaptive signature design100
  • NOTE: Treatment effect restricted to sensitive patients. Ten percent of patients sensitive, 10 sensitivity genes (98% response rate in sensitive patients and 25% response rate in nonsensitive patients on the new treatment arm; 25% response rate for all control arm patients).