Table 2

Association of breast cancer survival with PVUII, XbaI, and (GT)n polymorphisms in the ER-α gene: Shanghai Breast Cancer Study

nNo. deathsHR (95% CI) unadjustedHR (95% CI) adjusted*
ER-α, PVUII
    pp408731.00 (reference)1.00 (reference)
    Pp509750.83 (0.60-1.15)0.73 (0.51-1.04)
    PP135241.01 (0.63-1.59)0.95 (0.57-1.56)
ER-α, XbaI
    xx531931.00 (reference)1.00 (reference)
    Xx493730.87 (0.64-1.18)0.80 (0.56-1.12)
    XX3660.97 (0.43-2.22)1.16 (0.50-2.68)
ER-α, (GT)n repeats
    No (GT)15 alleles7291221.00 (reference)1.00 (reference)
    One (GT)15 allele203320.93 (0.63-1.37)1.00 (0.68-1.48)
    Two (GT)15 alleles120
    No (GT)16 alleles319511.00 (reference)1.00 (reference)
    One (GT)16 allele464771.04 (0.73-1.48)1.07 (0.75-1.53)
    Two (GT)16 alleles161260.98 (0.61-1.58)1.01 (0.63-1.62)
    No (GT)17 allele8421391.00 (reference)1.00 (reference)
    One (GT)17 allele98150.94 (0.55-1.60)1.03 (0.60-1.75)
    Two (GT)17 alleles40
    No (GT)18 allele7041021.00 (reference)1.00 (reference)
    One (GT)18 allele222491.62 (1.15-2.28)1.61 (1.15-2.27)
    Two (GT)18 alleles1831.13 (0.36-3.56)1.03 (0.33-3.27)
    No (GT)23 allele7571301.00 (reference)1.00 (reference)
    One (GT)23 allele172210.69 (0.44-1.10)0.66 (0.42-1.05)
    Two (GT)23 alleles1631.08 (0.35-3.41)1.03 (0.32-3.24)
  • * Adjusted for age at diagnosis, stage of disease, and radiotherapy.