Table 2

Impact of imatinib on cytokine and chemokine secretion of mature MDCs

+DMSO+Imatinib
3 μmol/L3 μmol/L (day 4)
Monocyte chemoattractant protein-1 (CCL2; pg/mL)
    Donor 1>10,0004,172.54,820
    Donor 2>10,0003,711.5ND
    Donor 3>10,0007,692.56,649.5
Rantes (CCL5; pg/mL)
    Donor 18,7587351,817
    Donor 2>20,0007,865ND
    Donor 3>20,0006,8379,687
Macrophage inflammatory protein-1α (CCL3; pg/mL)
    Donor 11,317432485
    Donor 22,212967ND
    Donor 34,4301,8501,652
IL-6 (pg/mL)
    Donor 13,1213,0232,975
    Donor 23,1072,954ND
    Donor 33,2943,3693,198
IL-12 (pg/mL)
    Donor 1>1,00043.9425.6
    Donor 2>1,000705.0ND
    Donor 3801.918.291.3