Table 1.

Posttreatment differential gene expression in docetaxel + A12–treated tumors compared with docetaxel alone–treated tumors

HUGONameGO functionFold changeFalse discovery rate (%)
Down-regulated genes
    CDC2Cell division cycle 2Cytokinesis; mitosis3.0≤0.02
    CDC6CDC6 cell division cycle 6 homologueNegative regulation of cell proliferation2.2≤0.02
    CCNA2Cyclin A2Regulation of CDK activity2.1≤0.02
    MYBL2V-myb myeloblastosis viral oncogene homologue (avian)-like 2Antiapoptosis; development; regulation of cell cycle3.2≤0.02
    TUBBTubulin β polypeptideMicrotubule-based movement taxane resistance2.3≤0.02
    K-Alpha-1Tubulin α ubiquitousMicrotubule-based movement taxane resistance2.5≤0.02
    BIRC5Baculoviral IAP repeat-containing 5 (survivin)Antiapoptosis2.5≤0.02
    CDC25BCell division cycle 25BPositive regulation of cell proliferation2.0≤0.02
    MYCV-myc myelocytomatosis viral oncogene homologue (avian)Cell cycle arrest2.5≤0.02
Up-regulated genes
    TOB1Transducer of ERBB21Negative regulation of cell proliferation2.2≤0.02
    CCNG2Cyclin G2Cell cycle checkpoint2.1≤0.02
    IGFBP3IGF binding protein 3Regulation of cell growth, proapoptotic2.0≤0.02
    BIRC3Baculoviral IAP repeat-containing 3Antiapoptosis; cell surface receptor–linked signal transduction2.2≤0.02