Table 3.

Pharmacokinetics variables

Dose level (mg/m2)n17-AAG
17-AG
Cmax (μmol/L)t1/2 (h)AUC (μmol/L*h)Cl (L/h/m2)Vss (L)Cmax (μmol/L)t1/2 (h)AUC (μmol/L*h)
5711.44.843.032.2120.20.5710.533.60
8013.05.436.820.291.10.698.963.26
11211.94.065.932.5119.30.508.472.55
15716.84.0515.017.959.61.026.097.29
2206*
    mean10.23.1321.818.748.62.694.9216.01
    SD2.80.885.85.117.01.661.0711.11
3082
    mean16.82.7553.210.129.95.874.9359.29
    SD4.50.0910.62.01.31.510.4113.22
  • Abbreviations: Vss, steady-state volume of distribution; Cl, clearance.

  • * Seven patients were treated; however, data for only six patients are available.