Table 2.

Univariate and multivariate Cox regression analyses of clinicopathologic factors and the expression of DICER1, DGCR8, RNASEN in esophageal cancer

VariablesHR (95% CI)Unfavorable/favorableP
Univariate Cox regression analysis
    Age(y)1.18 (0.63-2.19)≤65/>650.60
    Gender1.23 (0.57-2.67)Male/female0.59
    Disease stage4.61 (3.44-11.82)III-IV/0-II0.0006
    Primary tumor5.14 (3.40-9.79)pT3,4/pT1,20.0007
    Lymph node metastasis3.83 (1.50-11.03)+/−0.0050
    Vein invasion2.40 (1.08-5.31)+/−0.031
    Lymphatic invasion4.02 (0.93-17.46)+/−0.017
    Histology1.38 (0.49-3.92)Poor/well or moderate0.54
    DICER11.23 (0.65-2.31)High/low0.53
    DGCR81.64 (0.89-3.01)High/low0.11
    RNASEN2.88 (1.55-5.34)High/low0.0008
Multivariate Cox regression analysis
    Disease stage5.62 (1.35-23.46)III-IV/0-II0.018
    Lymph node metastasis1.24 (0.30-5.19)+/−0.76
    Vein invasion2.38 (0.91-6.21)+/−0.076
    Lymphatic invasion1.87 (0.27-13.05)+/−0.53
    Histology2.91 (0.68-12.48)Well or moderate/poor0.15
    DICER13.15 (0.71-13.96)Low/high0.18
    DGCR82.37 (0.67-8.36)High/low0.17
    RNASEN4.56 (1.52-13.75)High/low0.0069
  • Abbreviations: HR, hazard ratio; 95% CI, 95% confidence interval.