Table 2.

Correlation between clinicopathologic characteristics and VHL alteration status and VCAM1 expression levels in patients with clear cell RCC

Characteristicn (%)VCAM1 expression level, median (interquartile range)P
Age (y)
    ≤59186 (43)1.814 (2.429)0.861*
    ≥60243 (57)1.953 (2.501)
Sexual distribution
    Female119 (28)2.189 (2.370)0.364*
    Male310 (72)1.820 (2.460)
Symptom presentation
    Negative243 (57)2.163 (2.539)<0.001*
    Positive186 (43)1.250 (2.614)
Tumor size (cm)
    ≤4.5188 (44)2.207 (2.456)0.001
    4.6-9.4182 (43)1.746 (2.228)
    ≥9.559 (14)1.060 (2.948)
UICC stage
    I226 (53)2.241 (2.433)<0.001
    II18 (4.2)2.275 (2.066)
    III83 (19)1.841 (2.753)
    IV102 (24)0.988 (2.142)
Tumor grade
    G1116 (27)2.069 (2.070)<0.001
    G2185 (43)2.113 (2.524)
    G3 + G4128 (30)1.065 (2.871)
Microvascular invasion
    Negative + not determined271 (63)2.315 (2.330)<0.001*
    Positive158 (37)1.472 (2.664)
VHL alteration (n = 219)
    Positive116 (53)2.131 (2.126)0.001*
    Negative103 (47)1.271 (2.017)
  • * Mann-Whitney U test.

  • Kruskal-Wallis H test.