Table 1.

Dose escalation schema

StratumDose levelGefitinib dose (mg/d)Sirolimus
Loading dose (mg)Maintenance dose (mg/d)
Stratum A*1500155
25003010
37503010
Stratum B
11,000155
21,0003010
31,5003010
  • * Stratum A: patients not on EIAEDs (phenytoin, phenobarbitol, carbamazepine, oxcarbazepine, and primidone).

  • Stratum B: patients on EIAEDs.