Table 5.

Gefitinib pharmacokinetic variables

Dose levelDaynAUCss (ng h/mL)
Css,max (ng/mL)
Tmax (h)Css,min (ng/mL)
CLss/F (mL/min)
GmeanCV (%)GmeanCV (%)GmeanCV (%)GmeanCV (%)
Stratum A: no EIAEADs*
    17411,60078.764094.2637573.672078.7
10411,70067.960783.0437254.971567.9
    2759,06089.854271.7427210392189.7
1059,67066.259148.4427489.686266.3
Stratum B: on EIAEADs*
    1739,11035.953730.9227643.61,83035.6
1039,28014.263516.7421421.61,80014.3
    2
735,65079.0387103413885.72,95079.1
1035,38092.632084.1415199.83,10092.8
  • Abbreviations: Gmean, geometric mean; CV%, coefficient of variation.

  • * EIAEADs: phenytoin, carbamazepine, oxcarbazepine, phenobarbitol, primidone.