Table 1.

Marker expression in bronchoscopy tissue (worst tissue specimens)

Marker expression
EGFR, average score (n)HER-2, average score (n)Ki-67, average % positivity (n)MCM2, average % positivity (n)
Histology*
    11.47 (16)1.69 (16)10.94 (16)72.94 (16)
    21.53 (16)1.91 (16)20.31 (16)63.09 (16)
    31.86 (7)2.00 (7)26.14 (7)79.43 (7)
    41.67 (18)1.94 (18)46.28 (18)86.61 (18)
    51.84 (38)1.87 (38)52.27 (37)80.47 (38)
    61.90 (21)1.90 (21)48.24 (21)87.86 (21)
    72.00 (4)2.00 (4)69.50 (4)86.00 (4)
    82.00 (14)2.00 (14)66.75 (14)96.04 (14)
    P<0.0010.102<0.0010.001
Smoking
    Current1.79 (50)1.92 (50)49.64 (50)84.64 (50)
    Former1.81 (68)1.88 (68)40.19 (67)78.00 (68)
    Never1.54 (14)1.82 (14)33.68 (14)82.61 (14)
    P0.160.410.040.42
Age
    37-491.62 (13)1.77 (13)36.00 (13)78.54 (13)
    50-591.70 (32)1.92 (32)44.84 (32)81.22 (32)
    60-691.84 (51)1.83 (51)41.58 (50)79.05 (51)
    70-791.79 (31)1.98 (31)41.34 (31)85.37 (31)
    80-841.71 (7)2.00 (7)58.86 (7)83.57 (7)
    P0.220.170.420.47
Gender
    Female1.68 (36)1.81 (36)38.10 (35)76.46 (36)
    Male1.80 (98)1.92 (98)44.31 (98)82.96 (98)
    P0.130.130.290.21
  • * 1 = normal, 2 = basal cell hyperplasia, 3 = squamous metaplasia, 4 = mild dysplasia, 5 = moderate dysplasia, 6 = severe dysplasia, 7 = carcinoma-in-situ, 8 = carcinoma.

  • P values test the linear trend across histologic grade, smoking status, age, or gender.