Table 2.

Per treatment group, the administered and measured end-treatment amount of pemetrexed

Treatment dose (mg/kg)Administered
End treatment
Concentration (mg/mL)Total amount (mg)Concentration (mg/mL)Urine volumeTotal amount (mg)
53.8 (3.6-3.9)190 (182-198)3.2 (2.8-3.6)59 (56-61)188 (154-221)
106.8 (6.7-7.0)341 (334-348) 5.8 (5.5-6.0)66 (64-68)380 (373-386)
1510.7 (9.7-11.6)537 (485-578)7.0 (4.7-8.8)53 (46-61)367 (248-449)
2014.0 (13.8-14.2)699 (688-710)10.2 (9.6-10.9)59 (49-65)607 (492-617)
2517.4 (17.0-17.8)869 (850-888)8.9 (7.9-9.9)82 (78-85)727 (613-841)
3021.7 (21.5-22.0)1,086 (1074-1,098)10.4 (7.1-16.6)89 (70-126)866 (507-1163)
1 × 3020.1 (19.5-20.8)1,006 (975-1,026)12.8 (6.2-27.1)100 (49-167)1,051 (830-1,327)
2 × 3020.3 (19.7-21.1)1,015 (984-1,053)14.8 (7.2-25.9)81 (58-143)1,105 (640-1,994)
3 × 3020.2 (19.3-20.7)1,009 (966-1,035)15.8 (14.6-18.0)72 (42-116)1,128 (635-1,693)
4 × 3021.4 (21.1-21.8)1,069 (1,056-1,089)18.3 (10.6-24.4)65 (51-86)1,184 (699-1,806)
5 × 3023.1 (22.6-23.6)1,155 (1,128-1,182)16.3 (13.3-19.7)62 (42-78)997 (621-1,221)
6 × 3023.1 (22.1-23.9)1,155 (1,104-1,194)19.2 (15.1-24.0)67 (56-85)1,292 (912-2,040)
  • NOTE: Mean concentration and total amount (lowest and highest values). The values were not rounded for the calculations that are made.