Table 3.

Per dose of pemetrexed, the mean histopathologic item score (maximum score per group), based on a 0 to 3 score per biopsy

Treatment dose (mg/kg)CasesTotal no. biopsiesSubmucosa
Mucosa
EdemaHyperaemiaErythrocyte extravasationNeutrophil infiltrationLymphocyte infiltrationNeutrophil infiltrationLymphocyte infiltration
03120.08 (1)0.08 (1)0 (0)0.17 (1)0.33 (2)0 (0)0 (0)
5280 (0)0 (0)0 (0)0 (0)0.88 (1)0 (0)0 (0)
10280.63 (1)0.75 (1)0.75 (1)0.88 (2)1.13 (2)0.88 (2)1 (2)
153120.25 (1)0.42 (1)0.25 (1)0.25 (1)0.83 (2)0.17 (2)0.17 (2)
203120.08 (1)0.33 (1)0.42 (2)0.17 (1)0.50 (1)0.17 (2)0.17 (1)
25280.38 (1)0.63 (1)0 (0)0.63 (1)1.00 (2)0.50 (1)0.75 (2)
303120.75 (1)1.08 (2)0.75 (1)1.00 (1)0.25 (1)0 (0)0 (0)
6 × 305200.80 (2)1.15 (2)0 (0)0.60 (1)1.30 (2)0.75 (2)0.70 (2)