Table 4.

Growth parameters, metastasis occurrence, and drug response of HBC xenografts

Growth parameters
Drug response
Tumor xenograft codeDoubling time* (days)Lung metastasis positive/total nb (%)TreatmentsTumor growth inhibition (%)T/C Growth delay indexComplete response (%)Responder§
HBCx-1151/6AC90No regrowth100High R
Docetaxel6120R
HBCx-2101/15 (7%)AC181.20No
Docetaxel181.10No
HBCx-380/20 (0%)AC461.60No
Docetaxel401.60No
Degarelix602.40R
HBCx-4100/11 (0%)AC501.60No
Docetaxel110No
HBCx-5815/17 (88%)AC90No regrowth0R
Docetaxel78No regrowth0R
Trastuzumab471.10No
HBCx-6140/2AC100No regrowth100High R
Docetaxel111.10No
HBCx-790/9 (0%)AC471.40Low R
Docetaxel87No regrowth25R
HBCx-853/29 (10%)AC100No regrowth100High R
Docetaxel421.60Low R
HBCx-950/23 (0%)AC68No regrowth0R
Docetaxel100No regrowth25R
HBCx-10171/19 (5%)AC100No regrowth100High R
Docetaxel481.10No
HBCx-11141/4AC85No regrowth0R
Docetaxel481.70Low R
HBCx-13133/14 (21%)AC100No regrowth100High R
Docetaxel461.050No
Trastuzumab95No regrowth100High R
HBCx-14107/8 (88%)AC80No regrowth0R
Docetaxel231.70No
HBCx-1540/23 (0%)AC99No regrowth100R
Docetaxel421.40No
HBCx-12716/16 (100%)AC5220R
Docetaxel2810No
HBCx-16171/2AC73No regrowth0R
Docetaxel1910No
HBCx-17
120/3AC100No regrowth100High R
Docetaxel421.20No
  • Abbreviation: AC, Adriamycin-cyclophosphamide combination.

  • * Time in days required to double the tumor size, during the exponential phase of growth.

  • TGI (tumor growth inhibition) is the optimal ratio between the mean tumor volume in the treated group and that in the control group × 100, at the same time.

  • T/C growth delay index is the ratio between the survival of treated mice and the survival of control mice. This index cannot be calculated in case of complete response.

  • § Four categories of HBCx responders (R) were defined as detailed in Materials and Methods: (a) high R, (b) responders (R), (c) Low R; and (d) the nonresponders (Not in the tables).