Table 1.

Significant genomic aberrations (adjusted P < 0.05) and their frequencies among distinct breast tumor groups and recurrent high-level DNA amplifications

Chromosomal regionFrequencies of alteration (%)Two-sided adjusted Fisher's exact P
BRCA1BRCA2BRCAXSporadicB1vsB2B1vsBXB1vsSB2vsBXB2vsSBXvsS
Gain
    8q22.1587932740.023
    8q23.1-8q23.3748335740.010
    8q23.3-8q24.13798335740.010
    8q24.13-8qtel848339740.0770.025
    11q14.147010100.005
Loss
    4q2332126530.020
    4q2437126580.005
    4q2547126580.0740.005
    4q26-4q28.142126580.005
    4q28.242169580.031
    4q28.3421610630.022
    4q31.142813630.0090.022
    4q31.2137816630.009
    4q32.1-4q32.2471223630.044
    4q32.3521223630.044
    4q33-4q34.1581226630.044
    4q34.2-4q35.1581223630.044
    4q35.1-4q35.2521226630.044
    13q12.3475016680.013
    13q13.1-13q13.3535016680.013
    13q13.3-13q14.11585416680.013
    13q14.11-13q14.3635416680.0970.013
    13q14.3-13q21.33685416580.019
    13q22.1-13q22.2684216580.019
    13q22.2-13q22.3684219580.048
    13q31.1634219530.026
    21q21.31103420.0250.046
High-level DNA amplifications
    8p12-8p11.23118616
    8p11.22-8pcen114316
    8q22.1-8q22.35171016
    8q23.1-8q23.311211021
    8q24.1132371621
    8q24.12-8q24.2137371621
    8q24.21-8q24.2237291326
    8q24.23-8qtel21251026
    10ptel-10p15.300016
    10p15.2110016
    10p15.100016
    10p1450016
    11q13.3-11q13.41112160
    12p13.32-12p13.3116005
    13q34-13qtel164011
  • NOTE: Frequency aberrations >50% are in bold. Entries in italics show P < 0.05. In addition, those high-level DNA amplifications with a frequency >15% (in bold) in at least one tumor group are shown.